Why Do I Still Have Thyroid Symptoms?
When My Lab Tests are Normal

7 causes of hypothyroidism

Only ONE of which requires thyroid drugs, if even then

Hashimoto’s autoimmune thyroid disease

Hypothyroidism caused by mental or metabolic stress

Primary hypothyroidism

Under-conversion to active thyroid hormone

Over-conversion to active thyroid hormone

Too many proteins bind to thyroid hormone so it can’t get inside cells

Cells become resistant to thyroid hormone

Finally — the book that provides real answers for those still suffering from hypothyroidism or Hashimoto’s!

Order your copy of Dr. Kharrazian’s (my mentor) book at www.thyroidbook.com

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Listen to Dr. Datis Kharrazian’s radio interview from February 2, 2010

Audio Part 1

Audio Part 2

Why Do I Still Have Thyroid Symptoms?
When My Lab Tests are Normal

7 causes of hypothyroidism
Only ONE of which requires thyroid drugs, if even then
Hashimoto’s autoimmune thyroid disease
Hypothyroidism caused by mental or metabolic stress
Primary hypothyroidism
Under-conversion to active thyroid hormone
Over-conversion to active thyroid hormone
Too many proteins bind to thyroid hormone so it can’t get inside cells
Cells become resistant to thyroid hormone
Finally — the book that provides real answers for those still suffering from hypothyroidism or Hashimoto’s!

Get Dr. Kharrazian’s (my mentor) new book at www.thyroidbook.com

Journal of Clinical Endocrinology & Metabolism , doi:10.1210/jc.2008-0798

Celiac Disease
Thyroid Diseases

Related Collections

Thyroid

Autoimmunity

The Journal of Clinical Endocrinology & Metabolism Vol. 93, No. 10 3915-3921
Copyright © 2008 by The Endocrine Society

Risk of Thyroid Disease in Individuals with Celiac DiseasePeter Elfström, Scott M. Montgomery, Olle Kämpe, Anders Ekbom and Jonas F. Ludvigsson
Department of Pediatrics (P.E., J.F.L.) and Clinical Research Centre (S.M.M.), Örebro University Hospital, SE-701 85 Örebro, Sweden; Clinical Epidemiology Unit (S.M.M., A.E., J.F.L.), Department of Medicine, Karolinska Institutet, Karolinska University Hospital, SE-17176 Stockholm, Sweden; Department of Medical Sciences (O.K.), Uppsala University, University Hospital, SE-75123 Uppsala, Sweden; and Department of Primary Care and Social Medicine (S.M.M.), Charing Cross Hospital, Imperial College, W6 8RF London, United Kingdom

Address all correspondence and requests for reprints to: Peter Elfström, Department of Pediatrics, Örebro University Hospital, SE-701 85 Örebro, Sweden. E-mail: peter.elfstrom@orebroll.se.

Background: It has been suggested that celiac disease is associated with thyroid disease. Earlier studies, however, have been predominately cross-sectional and have often lacked controls. There is hence a need for further research. In this study, we estimated the risk of thyroid disease in individuals with celiac disease from a general population cohort.

Methods: A total of 14,021 individuals with celiac disease (1964–2003) and a matched reference population of 68,068 individuals were identified through the Swedish national registers. Cox regression estimated the risk of thyroid disease in subjects with celiac disease. Analyses were restricted to individuals with a follow-up of more than 1 yr and with no thyroid disease before study entry or within 1 yr after study entry. Conditional logistic regression estimated the odds ratio for subsequent celiac disease in individuals with thyroid disease.

Results: Celiac disease was positively associated with hypothyroidism [hazard ratio (HR) = 4.4; 95% confidence interval (CI) = 3.4–5.6; P < 0.001], thyroiditis (HR = 3.6; 95% CI =1.9–6.7; P < 0.001) and hyperthyroidism (HR = 2.9; 95% CI = 2.0–4.2; P < 0.001). The highest risk estimates were found in children (hypothyroidism, HR = 6.0 and 95% CI = 3.4–10.6; thyroiditis, HR = 4.7 and 95% CI = 2.1–10.5; hyperthyroidism, HR = 4.8 and 95% CI = 2.5–9.4). In post hoc analyses, where the reference population was restricted to inpatients, the adjusted HR was 3.4 for hypothyroidism (95% CI = 2.7–4.4; P < 0.001), 3.3 for thyroiditis (95% CI = 1.5–7.7; P < 0.001), and 3.1 for hyperthyroidism (95% CI = 2.0–4.8; P < 0.001).

Conclusion: Celiac disease is associated with thyroid disease, and these associations were seen regardless of temporal sequence. This indicates shared etiology and that these individuals are more susceptible to autoimmune disease.

Global Physiological Effects of Thyroid Hormone
An estimated 27 million Americans suffer from thyroid-related illness, the majority of them women. Yet thyroid-related diseases are often ill diagnosed, and there is much about their treatment that bears greater clarification and study. In Dr. Datis Kharrazian’s book “Why do I still have thyroid symptoms When all my labs are normal?” he presents a revolutionary breakthrough in understanding Hashimoto’s and hypothyroidism and supporting people who have these conditions. There are 7 patterns of of low thyroid function that can be indentified using blood tests. Only one of the patterns responds to thyoid replacement therapy.

Global Physiological Effects of the Thyroid
1. GI Motility. Generally gastrointestinal motility is decreased in hypothyroid states. A decrease in gastrin leads to a decrease in HCL acid which is necessary to breakdown food.

2. Anemias. Due to a decrease in absorption of nutrients, iron defiency anemia is often present. Also, pernicious anemia is common in about 12% of all hypothyroid patients due to autoimmune attacks against the parietal cells in the gut responsible for producing intrinsic factor.

3. IGF1. IGF1 is decreased in hypothyroid states which helps in the anabolic repair/rebuilding of the body.

4. Epinepherine/Norepinepherine. These 2 neurotransmitters lose their function in hypothyroid states and lead to loss of motivation and depression. They are also responsible for lypolysis, which is the breakdown of fat, this leads to difficulty losing weight.

5. Hepatic clearance. Phase 2 conjugating enzymes can’t mature in a hypothyroid state and this inhibits the clearance of toxins.

6. Progesterone. Progesterone receptor sites lose their sensativity to take in progesterone and often times we will see a spike or increase in serum progesterone, yet a patient has symtoms of decreased progesterone.

7.SHBG. Sex hormone binding globulin is increased in hypothyroid states and this decreases the ability of testosterone and estrogen to get into the cells, causing symptoms of defiecency.

As you can see, the thyroid has a dramatic effect of many physiological sysytems.

Most, (80-90%), of all hypothyroid conditions are autoimmune in origin, meaning the body is attacking itself. In these instances, replacement therapy (natural or synthetic) will have very little effect on the long term success in management of these conditions. In our office, after a comprehensive blood panel, (including a breakdown and dissection of the whiet blood cells) we determine if it is in fact an autoimmune condition. If it is, we have specific management protocols that address the autoimmune component and help to modulate the genetic expression of the condition.

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Dr. Joe Alaimo, MA, DC
Chronic Pain and Metabolic Conditions

Melany Tarr
New Patient Coordinator

1202 S. 16th St.
Wilmington, NC 28401

910-251-1620

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HOW TO FINALLY END YOUR THYROID NIGHTMARE!
WHAT MAKES US DIFFERENT FROM EVERY OTHER DOCTOR THAT YOU HAVE SEEN?

We treat you metabolically and neurologically!

You are on this website because you or someone you love is suffering from thyroid disorder.

I am here to tell you that……

NO STONE IS LEFT UNTURNED TO DETERMINE THE EXACT CAUSE OF YOUR PROBLEM!

I WILL GUARANTEE YOU THAT NO ONE HAS TOLD YOU WHAT I AM ABOUT TO TELL YOU…….

I am going to address:

#1: What makes my program unique?

#2: How I successfully treat your thyroid problem.

HOW DO I SUCCESSFULLY MANAGE THYROID CONDITIONS?

By using specific metabolic and neurological protocols!

#1: SPECIFIC METABOLIC TESTING AND TREATMENTS:

I: Sensitivity Testing: to determine if you have a sensitivity to gluten (wheat, rye, oats, and barley), milk, eggs, yeast, and soy. If you are sensitive to ANY of these food groups, it could be making you’re your thyroid condition worse as it will increase inflammation in your brain and throughout your body!

IF you suffer from Hashimoto’s thyroiditis, you need to be off of all gluten….NOW!

Here are some of the symptoms of these sensitivities:

Chronic pain or fatigue

Frequent indigestion

Bloated after eating

Frequent loose bowel movements

Constipation

Mouth ulcers or sores

Vomit often

The only way to find out of you are suffering from any of these sensitivities is the run the test.

II. Complete Blood Panels

By using specific blood tests such as:

#1: A complete metabolic panel (CMP)

#2: A lipid panel

#3: A CBC (complete blood chemistry with auto differential)

We can assess your adrenal glands, liver, kidneys, red/white blood cells and gut function with the above lab tests. All can be affected with chronic health conditions. By addressing any problems with your adrenal glands, blood chemistry, or gut function, we can help you to heal faster. The CMP also allows us to check your blood glucose levels since glucose and oxygen are needed by the brain to function properly.

What other tests of the thyroid are necessary?

· Thyroid Stimulating Hormone (TSH): the message sent from a gland in the brain (pituitary) to the thyroid.

· Free T3: an important hormone produced by the thyroid gland, considered to be the more biologically active hormone of the thyroid.

· Free T4: another important hormone produced by the thyroid gland.

· Thyroid Binding Globulin (TBG): This test measures the amount of proteins in the blood that transport thyroid hormones to the cells. Elevated testosterone can lower TBG levels and elevated estrogen can raise TBG levels. Both can produce hypothyroid symptoms.

· Thyroid Antibodies (TGB & TPO): checked in suspected cases of autoimmune thyroid disorders (see below)

· Total T4: this is a reflection of how much total T4 hormone there is in the blood

· Free Thyroxine Index (FTI): this is an estimate of how much thyroxine is in the blood

· Resin T3 Uptake: this test measures the unsaturated binding sites on the thyroid proteins

III: Adrenal Stress Index (ASI) :

You can test the adrenal glands with a test called an Adrenal Stress Index. This is a salivary test much like DNA testing. The adrenal glands sit right above the kidneys and they are your “stress” organs meaning that they react to stress. If the patient has been or are currently under stress, this test is a must!

IF THE PATIENT SUFFERS FROM INSOMNIA AND/OR DIABETES, THIS TEST IS A MUST! IT WILL MEASURE THEIR CORTISOL LEVELS.

IV. Immune Panels—EXTREMELY IMPORTANT!:

You could be suffering from an auto immune condition. An autoimmune thyroid is called Hashimoto’s Thyroiditis. Your immune system could be attacking your thyroid. This is why the immune panels are so important and NOT just the TPO and TGB thyroid antibodies.

There are two parts to the immune system, TH1 and TH2.

IL- 2 and TNF-alpha = TH1

TH1 is T-cells. T-cells are the army that attacks and cleans up afterword. (Helper T-cells, Suppressor T-cells, NKC, regulatory T-cells, and macrophages.

IL-4 and IL-10 = TH2

TH2 is B-cells. B-cells make anti-bodies. They tell T-cells what to kill. If the testing comes back with a high B-cell count, the patient is TH2 dominant.

T and B Lymphocyte & Natural Killer Cell Panel

IL-2 ,TNF-alpha, IL-4, IL-10

Natural Killer Cell Activity

You will want to determine if there is an active antigen or dysregulation.

Active antigens are parasites, bacteria, virus, mold, yeast, fungi, protozoan, foods, chemicals, and heavy metals.

The best indicator for an active antigen as the cause of the patient’s abnormal dominance is the “Helper/Suppresor” ratio on the T & B cell panel. (also called “CD4:CD8” ratio).

The closer to 2.5 the ratio is (or if above that), the more likely it is that you’re dealing with an antigen.

If the ratio is below 1.2, then you are most likely dealing with a dysregulation problem.

V. Intestinal Permeability: This test is used to determine if the patient suffers from leaky gut syndrome (LGS).

LGS or Leaky gut syndrome describes a condition of altered or damaged bowel lining, caused by antibiotics, toxins, poor diet, parasites or infection can lead to increased permeability of the gut wall to toxins, microbes, undigested food, waste or larger than normal macromolecules. It has been proposed that these substances affect the body directly, while others postulate an immune reaction to these substances.

VI. HORMONE PANELS:
We can check hormone panels to determine if the patient suffers from low testosterone in males or low estrogen/progesterone levels in females. Symptoms related to decreased hormone levels may include depression, fatigue, mental fogginess, mood swings, hot flashes, sweating attacks, weight gain, and decreased physical stamina.

#2: SPECIFIC NEUROLOGICAL TESTING AND TREATMENTS:

#1: Oxygen therapy: Oxygen is fuel for your brain and nervous system. Your brain and nervous system need two things to survive…..fuel and activation. Fuel comes in the form of OXYGEN AND GLUCOSE. By using oxygen, we will help you heal faster. By using exercise with oxygen therapy (EWOT), we can increase firing to brain. By increasing firing of brain, we help MANY chronic conditions. (Oxygen therapy is ordered by our M.D.—Please see the O2 handout)

#2: Brain-Based Therapy (BBT): We use specific brain-based therapy such as:

Vibration Therapy: Vibration fires the back part of the brain called the cerebellum. One of the functions of the cerebellum is control of the spinal muscle.

We may also use auditory, visual, olfactory, and caloric stimulation to increase firing of brain.

Laser therapy: We use the LiteCure Class IV laser in our office which is the highest powered laser on the market. Laser therapy helps heal tissues. (www.LiteCure.com)

Non-surgical Spinal Decompression: NSSD creates a negative disc pressure and helps to remove pressure off of the nerve. It also provides a slow stretch of the muscles which fires up the spinal cord to increase firing of brain.

Once we have run the necessary tests to determine your specific condition, we can successfully treat you via proper neurological and all natural nutritional protocols.

Ask yourself the following questions:

#1: How has your thyroid condition affected your relationships, finances, family, or other activities?

#2: What has it cost you in time, money, happiness, sleep?

#3: Where do you picture yourself in the next one to five years if this problem is not taken care of soon?

#4: What is it worth to you if we could improve your condition?

Finally, share this information with a family member or friend.

Why We Use Oxygen

Why Do We Use Enhanced Air (Oxygen) With Our Treatment Program?

Your brain and nervous system need two things to survive: fuel and activation. Fuel comes in the form of glucose and oxygen. You get the glucose from the food you eat BUT as you age, your ability to utilize oxygen decreases. We are giving you oxygen to help you heal faster. We want to get you better as fast as possible.

PLUS…….The cerebellum is in the back part of your brain and it controls ALL of your spinal musculature as well as your balance and coordinated movement. When the cerebellum is not firing correctly, the muscles will spasm, the vertebra lock up and the disc will lose fluid and degenerate. When we get the cerebellum firing better, the spinal muscles will no longer be in spasm, the vertebra will move better and your disc will re-generate.

Do you remember those tests that we did to check your cerebellum (finger to nose, standing with eyes closed and feet close together, playing piano, touching your finger that is over your head, etc.)? The cerebellum is the most DEPENDENT area of the body when it comes to oxygen. So that is why we are giving you oxygen, to get you better faster by allowing your cerebellum to work better!

Is oxygen essential for brain activity?
The brain demands at least 20% of the body’s oxygen supply, when it doesn’t get this supply it can lead to issues such as sleep apnoea, poor concentration, forgetfulness, mood swings, restlessness, depressive thoughts and low drive.

Brain activity – Dr. Andrew Scholey, Division of Psychology, University of Northumbria: “Extra oxygen has been shown to enhance mental performance and memory recall in healthy active adults in several clinical studies”. Ref. Pmid: 10604851 (pubmed – indexed for medline)

Other Benefits:

STAY STRONG.

Fatigue has been reported by several studies as one of the most common symptoms experienced by people worldwide*.

*”Boosting Your Energy” A Special Health Report from Harvard Medical School, Harvard Health Publications, 2006

Every breath you take converts to energy. Human cells use nutrients from food and oxygen to create adenosine triphosphate (ATP), the energy source that fuels cell function. If your cells receive too little oxygen, they produce less energy. If your cells need more energy, they use more oxygen. That’s why your breathing rate increases when you exercise.

STAY ALERT.

Unlike muscles, your brain cannot store energy. It needs a steady flow of nutrients and oxygen to function normally. Oxygen deficiency can decrease your alertness, memory and judgment. Conditions that can reduce blood oxygen levels include:

•air pollution
•traveling to a higher elevation
•breathing stale air that has less than the normal 20-21% oxygen.

“Insufficient oxygen means insufficient biological energy that can result in anything from mild fatigue to life threatening disease. The link between insufficient oxygen and disease has now been firmly established.” Dr. W. Spencer Way, journal of the American association of physicians

What are the main benefits of using oxygen?
Studies have shown that oxygen helps:

•Stimulate brain activity
•Increase memory capacity
•Boost concentration
•Develop stronger alertness
•Raise energy levels
•Improve strength
•Build endurance
•Detox your blood
•Reduce stress
•Calm anxiety
•Alleviate tension headaches
•Remedy irregular sleeping patterns
•Help with cardiovascular activity
•Prevent lactic acid build up
•Strengthen the immune system
Medical Thoughts on Oxygen

“Extra oxygen enables you to recover more quickly from exertion. It allows someone to train and then exercise again.” – Dr. John Brewer, head of sports science at Lilleshall Human Performance Centre: Health and Fitness 1999.

“Oxygen can clear your head, help eliminate toxins, and give you a mind high” – Andy Davison exercise physiologist Cosmopolitan 2000.

“If you use oxygen for 20 minutes, muscles become loosened; headaches and stress seem to disappear. There is a renewed energy and a feeling of relaxation. I am confident oxygen works.” – Dr. Richard de Andrea Sunday Herald.

“Increases alertness, improves the body’s ability to burn fat and enhances physical performance.” – Howard Robbins D.P.M, for The Journal.

“Dr. Parris Kidd stated that ‘oxygen plays a pivotal role in the proper functioning of the immune system; i.e. Resistance to disease, bacteria and viruses.’ Dr. Stephen Levine stated that ‘we can look at oxygen deficiency as the single greatest cause of disease.’ thus the development of a shortage of oxygen in the blood could very well be the starting point for the loss of the immune system and the beginning of feared health problems such as Cancer, Leukemia, AIDS, Candida, seizures, and nerve deterioration.” B. Goulet – The Magic of Aerobic Oxygen – Focus on Nutrition.

“In all serious disease states we find a concomitant low oxygen state…low oxygen in the body tissues is a sure indicator for disease… Hypoxia, or lack of oxygen in the tissues, is the fundamental cause for all degenerative disease.” Dr. Stephen Levine, renowned molecular biologist author, Oxygen Deficiency: A concomitant to all degenerative illness.

“I have ME and Fabro-Myalgia and have suffered with this debilitating condition for more than twelve years. I saw an oxygen bar at a health event and needed to sit down and by chance tried the oxygen. After this for four days I felt so active, had no pain, no fatigue, and no exhaustion and even managed to clean my house out. I made frequent trips in my car to the tip and charity shop of which I am normally unable do. I even went out for a meal and went shopping which I’ve never been able to do.” Carol Mason from Patmoor, Staffordshire.

Exercise with Oxygen Therapy
Basically, the body’s ability to transfer oxygen from the lungs to the cells is perhaps the most significant factor in whether you live a healthy life or not. This transfer mechanism becomes damaged with age, and then susceptibility to illness increases. However, EWOT aids the body in repairing this vital mechanism.

The scientific aspect of EWOT is a little complex, but here is a basic explanation. Oxygen comprises 20% of the atmosphere. Atmospheric pressure is 760 mm and thus the partial pressure of oxygen entering the body’s lungs is about 150 mm. However, oxygen in the lungs is diluted considerably with carbon dioxide. As the environment becomes increasingly polluted, the oxygen we intake is more and more diluted by carbon dioxide leaving the body and in the atmosphere. After oxygen is diluted, its pressure is reduced to 100-110 mm. This pressure drives the oxygen from the lungs into the blood and via the arteries to the capillaries in the extremities of the body. The capillaries then release some of the oxygen to support individual cells.

Ideally, the pressure of the oxygen in the arteries will almost equal the pressure in the lungs. However, aging causes the arterial pressure to decrease to approximately 70 mm as opposed to 95 mm.

In order for the oxygen to reach the cells from the capillaries, it must dissolve into the water of the body. Unlike carbon dioxide, though, oxygen does not dissolve easily into liquid. The significance is this: Oxygen’s solubility is heavily dependent on the pressure driving it.

Dr. Rowen of Second Opinion explains Oxygen is extracted in the capillaries and when the blood comes out the venous end of he capillary, the average pressure of oxygen in the veins is about 40 mm early in life and drops to 35 mm by age 70. The difference in the pressure of oxygen between the arterial and venous sides reflects how well the oxygen is delivered and consumed.

In your 30s, the amount of oxygen released to the cells is significantly higher than in your 70s: a 30 year-old will release 55 mm (95-40) while a 70 year-old will release 35 mm (70-35). That’s a huge drop in the amount of pressure of oxygen your cells receive.

The problem is that when you age, the oxygen pressure falls. Thus, while the volume of oxygen may stay the same and it may appear you are getting enough, your may be oxygen deficient because there isn’t enough pressure to make use of the volume of oxygen.

The breakthrough of EWOT is that it raises the arterial pressure to youthful levels; it only involves breathing high levels of oxygen while exercising. Exercise increases the circulation, creating a greater pressure to drive oxygen into the capillaries. The increase in pressure facilitates the repair of the transfer mechanism. EWOT is effective for every conceivable condition because it improves the delivery of the most essential substance in tissue life and repair.

Frequently Asked Questions

Am I a candidate for Dr. Alaimo’s treatments?
Not all patients will be accepted into our program. Dr. Alaimo will make a determination of treatment acceptance after an initial evaluation.

Why do you use Oxygen Therapy?
Your brain and nervous system need two things to survive: Fuel and Activation. Fuel comes in the form of oxygen and glucose. As we age our ability to use oxygen decreases. Oxygen therapy will help you get better faster!

Are your treatments safe?
Yes, extremely safe and painless.

I go to a chiropractor now, what is the difference?
Dr. Alaimo is a board certified chiropractor who has devoted his practice to the treatment and management of chronic, difficult neurologic and metabolic conditions.

How do I get more information?
For a FREE informational DVD, just fill out the form on the home page. To listen to real patients talk about their success with brain-based therapy visit www.lifechangingcare.com.

Do I need to stop taking my medications?
Please be advised that Dr. Alaimo will never tell you to stop taking your medications. That’s called practicing medicine without a license. As your symptoms improve during the course of care, Dr. Alaimo will recommend that you return to your physician to adjust medication levels.

Will my insurance cover the treatments?
Every insurance policy is different and the staff at Dr. Alaimo’s office will check on your insurance coverage. We will advise you of any coverage or limitations of coverage before any care is initiated.

How much do your treatments costs?
It varies due to individual patient findings. After a thorough review of your case, Dr. Alaimo will determine the course of care for your specific case

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